At New York Medical College, the battle against cancer is waged on a daily basis at the Cancer Research Institute. Led by director Zbigniew Darzynkiewicz, M.D., Ph.D., professor of pathology, the institute was established in 1990 to study the basic mechanisms involved in the control of cell proliferation and cell death as they relate to the differences between normal and cancer cells. Researchers utilize these new insights to develop effective tools for the diagnosis, classification and monitoring of treatment of individual patients.
Dr. Darzynkiewicz is joined by Frank Traganos, Ph.D., professor of medicine, in collaboration with clinical oncologists Tauseef Ahmed, M.D., professor of medicine and chief of the oncology and hematology division, and Karen P. Seiter, M.D.’85, professor of medicine and director of the Leukemia Service at New York Medical College and Westchester Medical Center, to examine cell cycles and aspects of cell death as predictors for which cancers will be most receptive to chemotherapy, and which will need more aggressive treatment regimens.
In another collaboration, Raj Tiwari, Ph.D. and Jan Geliebter, Ph.D., professors of microbiology and immunology, work with Steven Schaefer, M.D., professor of otolaryngology, and other clinicians and basic scientists to study the following:
- chemoprevention in thyroid cancer utilizing DIMs, a form of antioxidant found in cruciferous vegetables
- identification of biomarkers for diagnosis, prognosis, staging and monitoring of thyroid cancer using microarray technology and proteomics
- role of estrogens in the etiology of papillary thyroid cancer
- role of anti-estrogens in the control of thyroid proliferative diseases
Renato Rozental, M.D., Ph.D., professor of cell biology and anatomy, collaborates with Dr. Steven Schaefer and Simon Parisier, M.D., professor of otolaryngology, to study the molecular events that lead to cholesteatoma, a benign growth that acts like a neoplasm invading the ear and adjacent structures.
Meena Jhanwar-Uniyal, Ph.D., associate professor of pathology, collaborates with Raj Murali, M.D., professor and chairman of the Department of Neurology, to study genetic determinants of progression and dissemination of glioblastoma multiform and other tumors.