NYMC > Faculty > Directory > By Name > Lee, Sanghoon

Sanghoon Lee, Ph.D., M.Sc.

Assistant Professor of Pediatrics, Cell Biology and Anatomy

Email: sanghoon_lee1@nymc.edu


Department of Pediatrics,
Vosburgh Pavilion, Room 145 
New York Medical College
Valhalla, NY 10595

Personal Profile:

  • International Agency Research on Caner (IARC), World Health Organization (WHO), Lyon, France
  • Brigham and Women’s Hospital (BWH), Harvard Medical School, Boston, MA
  • Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA
  • Cancer Science Institute (CSI), National University of Singapore
  • New York Medical College, Valhalla, NY

Professional Interests:

  • Identifying targeted therapies for B-cell non-Hodgkin Lymphomas (B-NHL) including Burkitt Lymphoma (BL) and Primary mediastinal B-cell lymphoma (PMBL)
  • Mechanism(s) and characterization of Long non-coding RNA genes (lncRNA) and tumor suppressor/oncogenic micro RNAs (miR) in Pediatric BL
  • Preclinical translational studies in B-NHL                             
  • Developing in vitro and in vivo models of hematological malignancies using Homologous recombination system and molecular scissors (TALENs and CRISPR/Cas system) etc.

Education Profile:

Post Graduate Studies

  • Harvard Medical School, Boston, MA
  • International Agency Research on Caner (IARC), World Health Organization (WHO), Lyon, France

Graduate Degree: Ph.D., MSc.
Graduate Degree Institution: Republic of Korea (South)
Undergraduate Institution: Republic of Korea (South)

Selected Bibliography:

Lee S, F Roy, CM Galmarini, R Accardi, J Michelon, A Viller, E Cros, C Dumontet and BS Sylla. 2004. Frameshift mutation in the Dok1 gene in chronic lymphocytic leukaemia. Oncogene. 23(13): 2287-2297.

Lee S, C Andrieu, F Saltel, O Destaing, J Auclair, V Pouchkine, J Michelon, B Salaun, R Kobayashi, P Jurdic, E Kieff and BS Sylla. 2004. IkB kinase b phosphorylates Dok1 serines in response to TNF, IL-1, or g-radiation. Proc. Nat’l. Acad. Sci. USA. 101(50): 17416-17421.

Lee S, H Huang, Y Niu, M Tommasino, G Lenoir and BS Sylla. 2007. Dok1 gene mutation and expression in Burkitt's lymphoma cell lines. Cancer letters. 245: 44-50.

Ebralidze AK, FC Guibal, U Steidl, P Zhang, S Lee, B Bartholdy, M Alberich-Jorda, V Petkova, F Rosenbauer, G Huang, T Dayaram, J Klupp, K O’Brien, B Will, M Hoogenkamp, K Borden, C Bonifer and DG Tenen. 2008. PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. Genes and Development. 22:2085-2092.

Zhou YD, S Lee, Z Jin, M Wright, SEP Smith and MP Anderson. 2009. Arrested Maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsyNature Medicine15(10): 1208-1214(Highlighted in news and views of Nature Medicine, 2009).

Levantini E, S Lee, HS Radomska, CJ Hetherington, M Alberich-Jorda, G Amabile, P Zhang, D Gonzales, J Zhang, DS Basseres, NK Wilson, S Koshcmieder, G Huang, D-E Zhang, AK Ebralidze, C Bonifer, Y Okuno, B Gottgens, and DG Tenen. 2011. RUNX proteins mediate interaction of distal regulatory elements in hematopoietic stem cells. EMBO Journal. 30(19):4059-4070.

Staber PB, P Zhang, M Ye, R Welner, C Nombela-Arrieta, C Bach, M Kerenyi, BA Bartholdy, H Zhang, Alberich-Jorda M, S Lee, H Yang, Ng F, J Zhang, M Leddin, LE Silberstein, G Hoefler, SH Orkin, B Gottgens, F Rosenbauer, G Huang, and DG Tenen. 2013. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Molecular cell. 49(5):934-46.

Yong KJ, C Gao, B Tan, H Yang, J Lim, T Dimitrov, A Kawasaki, CW Ong, S Lee, S Ravikumar, S Sivastava, X Tian, JM Luk, YY Dan, M Salto-Tellez, L Chai, and DG Tenen. 2013. A novel role of stem cell factor SALL4 as a proto-oncogene in hepatocellular carcinoma. New England Journal of Medicine (NEJM).368(24):2266-2276.

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