Research Assistant Professor of Physiology
Department of Physiology
Basic Sciences Building Room 616
New York Medical College
Valhalla, NY 10595
My laboratory is interested in cellular alterations underlying the defective performance of the diseased heart and identification of corrective interventions aimed at restoring the functional properties of the myocardium. Our research is centered on signaling pathways activated in the heart following ischemic injury and the interplay between electrical properties of cardiomyocytes and contractile function of the aged heart.
Graduate Degree: Ph.D.
Graduate Degree Institution: University of Parma, Italy
Comelli M, Meo M, Cervantes DO, Pizzo E, Plosker A, Mohler PJ, Hund TJ, Jacobson JT, Meste O, and Rota M. Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice. Am J Physiol Heart Circ Physiol 319: H893-H905, 2020.
Meo M, Meste O, Signore S, and Rota M. Novel methods for high-resolution assessment of cardiac action potential repolarization. Biomed Signal Process Control 51: 30-41, 2019.
Borghetti G, Eisenberg CA, Signore S, Sorrentino A, Kaur K, Andrade-Vicenty A, Edwards JG, Nerkar M, Qanud K, Sun D, Goichberg P, Leri A, Anversa P, Eisenberg LM, Jacobson JT, Hintze TH, and Rota M. Notch signaling modulates the electrical behavior of cardiomyocytes. Am J Physiol Heart Circ Physiol 314: H68-H81, 2018.
Sorrentino A, Borghetti G, Zhou Y, Cannata A, Meo M, Signore S, Anversa P, Leri A, Goichberg P, Qanud K, Jacobson JT, Hintze TH, and Rota M. Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes. Am J Physiol Heart Circ Physiol 312: H150-H161, 2017.
Meo M, Meste O, Signore S, Sorrentino A, Cannata A, Zhou Y, Matsuda A, Luciani M, Kannappan R, Goichberg P, Leri A, Anversa P, and Rota M. Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm. J Am Heart Assoc 5, 2016.
Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, and Rota M. Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nat Commun 6: 8803, 2015.