Marina K. Holz, Ph.D., M.P.H. '23
Marina K. Holz, Ph.D., M.P.H. '23, leads an extramurally-funded laboratory studying the mechanisms of signaling by hormones and growth factors in breast cancer and lymphangioleiomyomatosis (LAM)—a rare lung disease. Her work spans basic science and clinical applications and has been published in leading journals. The Holz Lab has been previously funded by grants from the National institutes of Health (NIH), American Cancer Society (ACS), LAM Foundation, Cayman Biomedical Research Institute, Wendy Will Case Cancer Fund, American Association for Cancer Research (AACR), Mindlin Foundation, National Cancer Center, and the Department of Defense (DoD).
Dr. Holz is a dedicated mentor to students and laboratory scientists, with many of her trainees going on to successful health professional and biomedical research careers. She is a member of and has served as a mentor and coach in several diversity initiatives organized by the American Society for Biochemistry and Molecular Biology (ASBMB), the National Research Mentoring Network, and the American Society for Cell Biology. She was named a 2024 ASBMB 2024 fellow.
Education
- B.S., Microbiology and Immunology with Great Distinction, McGill University
- M.P.H., Health Policy and Management, New York Medical College
- Ph.D., Cell and Developmental Biology, Harvard Medical School
Honors and Awards
- Westchester Magazine “2019 Healthcare Hero”
- Outstanding Investigator Award, National Institutes of General Medical Sciences (NIGMS)
- AACR-Bayer Innovation and Discovery Award
- American Cancer Society Research Scholar Award
Publications
- Fard SS, Holz MK. "Regulation of mRNA translation by estrogen receptor in breast cancer." Steroids, 200(), (2023) 109316. doi: 10.1016/j.steroids.2023.109316
- Gupta N, Zhang B, Zhou Y, et. al. "Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis." Chest, 163(5), (2023) 1144-1155. doi: 10.1016/j.chest.2023.01.007
- Kundu N, Holz MK. "Lymphangioleiomyomatosis: a metastatic lung disease." American journal of physiology. Cell physiology, 324(2), (2023) C320-C326. doi: 10.1152/ajpcell.00202.2022
- Holz MK, Ballif BA, Gygi SP, et. al. "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events." Cell, 184(8), (2021) 2255. doi: 10.1016/j.cell.2021.03.060
- Nolan M, Knudson K, Holz MK, et. al. "Fanconi anemia and mTOR pathways functionally interact during stalled replication fork recovery." FEBS letters, 595(5), (2021) 595-603. doi: 10.1002/1873-3468.14035
- Torres AS, Holz MK. "Unraveling the multifaceted nature of the nuclear function of mTOR." Biochimica et biophysica acta. Molecular cell research, 1868(2), (2021) 118907. doi: 10.1016/j.bbamcr.2020.118907
- Faltas CL, LeBron KA, Holz MK, et. al. "Unconventional Estrogen Signaling in Health and Disease." Endocrinology, 161(4), (2020) . doi: 10.1210/endocr/bqaa030
Professional Service
- Editorial Board, Nature's Communication Biology
- Guest Associate Editor, PLOS Genetics
- Scientific Advisory Board of the LAM Foundation
- Committee on Women in Biochemistry and Molecular Biology of the American Society for Biochemistry and Molecular Biology (ASBMB)
- Peer reviewer for multiple journals
- Scientist Reviewer, grant review study sections
- Chair for NIH, DoD, ACS, LAM Foundation, and many international funding agencies
Memberships and Affiliations
- Advisory Member, Westchester Medical Center Cancer Committee
- Member of Leadership Group, Westchester Medical Center Breast Cancer Program
Teaching Responsibilities
- PATM-7101: Selected Topics in Cancer Biology
