Marcello Rota, Ph.D., leads a laboratory that is interested in cellular alterations underlying the defective performance of the diseased heart and identification of corrective interventions aimed at restoring the functional properties of the myocardium. Dr. Rota's research is centered on signaling pathways activated in the heart following ischemic injury and the interplay between electrical properties of cardiomyocytes and contractile function of the aged heart.

Education

• Ph.D., University of Parma

Areas of Expertise

• Basic cardiovascular science
• Electromechanical coupling
• Aging
• Heart failure

Publications

• Pizzo E, Cervantes DO, Ripa V, et. al. "The cAMP/PKA signaling pathway conditions cardiac performance in experimental animals with metabolic syndrome." Journal of molecular and cellular cardiology, 196(), (2024) 35-51. doi: 10.1016/j.yjmcc.2024.09.002
• Pizzo E, Cervantes DO, Ketkar H, et. al. "Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy." American journal of physiology. Heart and circulatory physiology, 326(6), (2024) H1424-H1445. doi: 10.1152/ajpheart.00325.2023
• Pizzo E, Berrettoni S, Kaul R, et. al. "Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals." Frontiers in cardiovascular medicine, 9(), (2022) 843144. doi: 10.3389/fcvm.2022.843144
• Cervantes DO, Pizzo E, Ketkar H, et. al. "Scn1b expression in the adult mouse heart modulates Na(+) influx in myocytes and reveals a mechanistic link between Na(+) entry and diastolic function." American journal of physiology. Heart and circulatory physiology, 322(6), (2022) H975-H993. doi: 10.1152/ajpheart.00465.2021
• Marino F, Scalise M, Salerno N, et. al. "Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age." Diabetes, 71(5), (2022) 1081-1098. doi: 10.2337/db21-0536
• Scalise M, Marino F, Salerno L, et. al. "In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes." Communications biology, 4(1), (2021) 1146. doi: 10.1038/s42003-021-02677-y
• Comelli M, Meo M, Cervantes DO, et. al. "Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice." American journal of physiology. Heart and circulatory physiology, 319(4), (2020) H893-H905. doi: 10.1152/ajpheart.00379.2020

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Teaching Responsibilities

• Co-director, Mammalian Physiology Course I and II, Graduate School of Biomedical Sciences.
• Dental Physiology Course, Touro College of Dental Medicine
• Fundamental Principles of Life, School of Medicine
• Cardiopulmonary Course, School of Medicine