Patric K. Stanton, Ph.D.

Professor, Cell Biology and Anatomy Biomedical SciencesProfessor, Neurology School of Medicine
Square

Education

  • B.S., Natural Sciences, Johns Hopkins University
  • Ph.D., Pharmacology, Uniformed Services University of the Health Sciences
  • Post-Graduate Studies, Neurophysiology, Max Planck Institute for Psychiatry
  • Post-Graduate Studies, Biophysics, The Johns Hopkins University 

Honors and Awards

  • Alexander von Humboldt Foundation Fellow
  • Klingenstein Fellow in the Neurosciences
  • Office of Naval Research Young Investigator Award
  • American Physiological Society Frontiers in Physiology Investigator

Research

Dr. Stanton's lab is investigating the cellular mechanisms underlying neuronal plasticity, including: 1) properties of long-term activity-dependent potentiation (LTP) and depression (LTD) of synaptic strength; 2) links between biochemical signaling cascades underlying LTD and LTP; 3) changes in synaptic function and structure associated with Alzheimer’s disease, traumatic brain injury, depression, stroke, migraine headache, perinatal lead exposure, and the development of epileptic seizures; and 4) cellular mechanisms that both trigger and prevent ischemia-induced delayed neuronal death. They were the first to show that induction of mammalian LTP requires cyclic AMP and new protein synthesis, to characterize a form of LTD evoked when presynaptic inputs are active while postsynaptic neurons are hyperpolarized, and to discover that traumatic brain injury and chronic depression are associated with long-lasting damage to neuronal and axonal structure and impairments in long-term synaptic plasticity, which can be reversed by new drug treatments that they have developed that are now in clinical trials. His lab discovered a bi-directional cyclic nucleotide regulation of synaptic strength, chemical methods of inducing this and other forms of LTD and pioneered the direct two-photon fluorescence imaging of presynaptic transmitter release to demonstrate that this form of LTD persistently alters the presynaptic transmitter release apparatus and glutamate release from the rapidly-recycling pool of transmitter vesicles. They employ extracellular and whole-cell patch clamp recordings, two-photon excitation and confocal fluorescence imaging of functional synaptic networks in both acute in vitro slices and organotypic slice cultures from hippocampus and medial prefrontal neocortex.

Publications

    View All Publications

    Professional Service

    • Editor-in-chief, NeuroReport
    • Editor-in-chief, Journal of Bioenergetics & Biomembranes
    • NIH External Advisory Committee, University of New Mexico Center for Brain Recovery and Repair
    • Member, Society for Neuroscience, International Brain Research Organization, New York Academy of Sciences, Society for Toxicology, Union of Concerned Scientists
    • NYMC:
    • Chair, Animal Care and Use Committee, New York Medical College
    • Faculty Senate Executive Committee – Regional Vice President for Basic Sciences, New York Medical College
    • School of Medicine Strategic Initiative Committee, New York Medical College
    • School of Medicine Anti-Racism and Anti-Bias Task Force, New York Medical College
    • Dean’s Research Committee, New York Medical College
    • Middle States Accreditation Steering Committee, New York Medical College

    Teaching Responsibilities

    • Cellular Mechanisms of Learning and Memory
    • Medical Neuroscience