Marvin S. Medow, Ph.D., is clinically interested in the regulation of heart rate and blood pressure in children and adolescents. Circulatory physiology remains ill-determined in children with a variety of problems with neurovascular dysfunction. His lab has established a Center for Hypotension-Related Disease aimed at young people from childhood through young adult with neurally mediated syncope, chronic orthostatic intolerance, chronic fatigue syndrome, orthostatic intolerance of other etiologies such as occur in the postural tachycardia syndrome (POTS). His research focus is on circulatory and vascular problems and their autonomic consequences including altered peripheral arterial and venous properties and changes in blood volume and its redistribution. Molecular mechanisms including cytokine and nitric oxide assessment are explored. Treatment protocols are tested. Methods include plethysmographic measurements of peripheral and central blood flow, capacitance and peripheral permeability measurements, skin blood flow measurements using laser-Doppler flowmetry, baroreflex assessment, standard circulatory autonomic function tests, assessment of the efficacy of the skeletal muscle pump, and tests of heart rate and blood pressure variability. Orthostatic stress is used as a provocative stimulus.

Areas of Expertise

• Pediatrics/Pediatric Gastroenterology, Hepatology and Nutrition
• Postural Tachycardia Syndrome (POTS)
• Hypotension
• Syncope
• Chronic Fatigue Syndrome (CFS)
• DOD Gulf War Syndrome
• Fibromyalgia

Education

• B.S., Biology, CUNY Lehman College
• Ph.D., Cornell University Medical College
• Fellowship, Biochemical Development and Metabolic Diseases, Children's Hospital of Philadelphia

Publications

• Stewart JM, Medow MS. "Can standing replace upright tilt table testing in the diagnosis of postural tachycardia syndrome (POTS) in the young?" Clinical autonomic research : official journal of the Clinical Autonomic Research Society, (), (2024) . doi: 10.1007/s10286-024-01080-x
• Pianello SR, Abouezzi JM, Weber GM, et. al. "Do Program Directors of Anesthesiology Residency Programs Interpret Narrative Letters of Recommendation as Intended?" Cureus, 16(7), (2024) e63573. doi: 10.7759/cureus.63573
• Medow MS, Stewart JM. "Phenylephrine alters phase synchronization between cerebral blood velocity and blood pressure in ME/CFS with orthostatic intolerance." American journal of physiology. Regulatory, integrative and comparative physiology, 326(6), (2024) R599-R608. doi: 10.1152/ajpregu.00071.2024
• Stewart JM, Visintainer P, Medow MS, et. al. "Standing tests lack reliability to diagnose all adolescents who have postural tachycardia syndrome." Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 33(6), (2023) 899-901. doi: 10.1007/s10286-023-00971-9
• Stewart JM, Medow MS. "Anticipatory central command on standing decreases cerebral blood velocity causing hypocapnia in hyperpneic postural tachycardia syndrome." Journal of applied physiology (Bethesda, Md. : 1985), 135(1), (2023) 26-34. doi: 10.1152/japplphysiol.00016.2023
• Boris JR, Abdallah H, Ahrens S, et. al. "Creating a data dictionary for pediatric autonomic disorders." Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 33(3), (2023) 301-377. doi: 10.1007/s10286-023-00923-3
• Stewart JM, Warsy IA, Visintainer P, et. al. "Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin." Hypertension (Dallas, Tex. : 1979), 77(4), (2021) 1234-1244. doi: 10.1161/HYPERTENSIONAHA.120.16113

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Professional Service

• Chair, New York Medical College Institutional Review Board for the Protection of Human Subjects (NYMC IRB)

Memberships and Affiliations

• American Autonomic Society